AQUIOS CL Safety Features for Handling Potentially Biohazardous Sample Material

Dr. Andreas Böhmler
April 29, 2020


AQUIOS CL Flow Cytometry System

AQUIOS CL SummaryAQUIOS CL Load and Go Flow Cytometer in Laboratory

The AQUIOS CL Flow Cytometry System incorporates the following features in one compact platform:

  • Automated sample loading,
  • Sample preparation,
  • Reagent management and barcode scanning, as well as data analysis and bidirectional LIS connectivity

AQUIOS CL: Load & Go Flow Cytometry

AQUIOS CL: Load & Go Flow Cytometry

LOAD & GO

  • Load blood samples, and receive results*
  • A flow cytometer where sample loading is as easy as on a hematology analyzer

PREPARES SAMPLES

  • Performs the entire preparation process

FREES UP TIME

  • User can focus on data review and validation of results

* Results require review by a qualified laboratory professional

AQUIOS CL: Available all Day, all WeekAQUIOS CL Casette Autoloader

  • Random-access loading of samples via cassette or single tube loader
  • On-board sample preparation incl. pipetting of antibodies and lysis reagent
  • Bi-directional LIS linkAquios CL On-board sample preparation
  • Comprehensive QC-Concept (incl. CAP and UK-NEQAS proficiency testing schemes)
  • Automated system setup: No dedicated daily setup reagents required
  • For In-Vitro-Diagnostic Use

AQUIOS CL Tests for TBNK Analysis

AQUIOS Tetra Tests for Automated Lymphocyte Subset Analysis

AQUIOS Tetra-1
  • AQUIOS Tetra system tests for simultaneous identification and enumeration of T, B, and NK lymphocytes in whole blood
  • Single Platform Technology (SPT) for lymphocyte subset analysis and enumeration without the need for counting beads.
  • AQUIOS Tetra-1 and AQUIOS Tetra-2+ are for In Vitro Diagnostic Use. AQUIOS CL with Tetra-1 has been accepted for the World Health Organization list of prequalified in vitro diagnostic products.

AQUIOS Tetra Tests for Automated Lymphocyte Subset Analysis

  FITC PE ECD PC5
AQUIOS Tetra-1
CD45
CD4
CD8
CD3
AQUIOS Tetra-2+
CD45 CD56+16
CD19
CD3

AQUIOS Catalog Products and Controls

Name PN Panel Status Availability
AQUIOS Tetra-1 B23533 CD45/CD4/CD8/CD3 CE / IVD / WHO-PQ North America, Europe, High-Growth Markets
AQUIOS Tetra-2+ B23534 CD45/CD56+16/CD19/CD3 CE / IVD North America, Europe, High-Growth Markets
AQUIOS IMMUNO-TROL Cells B23535 Process control (CD4 normal) CE / IVD North America, Europe, High-Growth Markets
AQUIOS IMMUNO-TROL Low Cells B25700 Process control (CD4 low) CE / IVD North America, Europe, High-Growth Markets

AQUIOS CL: Reduce exposure to potentially biohazardous material

AQUIOS Reduces Steps that Require Manual Intervention

AQUIOS Reduces Steps that Require Manual Intervention

  • AQUIOS accepts closed primary blood sample tubes.CARES Solutions Woman operating Aquios CL
  • No additional sample preparation, personnel, liquid handling modules or robots are required.
  • AQUIOS combines automated sample loading, sample preparation and cellular analysis into one compact system.

AQUIOS accepts closed primary blood sample tubes.

AQUIOS CL Casette Autoloader
  • Cassette autoloader
    • Cap piercing & mixing
    • Various tube types & sizes
    • Capacity: 8 cassettes/40 tubes
    • Continuous loading/unloading
  • Single-tube loader
    • Open or closed vial samplingAquios CL Single-tube loader
    • For additional tube sizes
    • Stat sampling capability
    • Manual mixing

 

AQUIOS CL Reduces Exposure to Potentially Biohazardous Material

AQUIOS CL Load and Go Flow Cytometer in labAQUIOS CL reduces exposure to potentially biohazardous material by…

  • Reducing the number of steps that require manual intervention
  • Accepting closed primary blood tubes
  • Cap piercing technology
  • Automated sample preparation
  • Touch screen operation

Download the AQUIOS brochure

AQUIOS CL: Provide a 24/7 Flow Cytometry Service

AQUIOS CL can be Run Safely by Less Experienced Operators

AQUIOS CL allows labs to allocate staff resources for maximum productivity, by…

  • Providing a flow cytometry system where sample loading is as easy as on a hematology analyzer
  • Minimizing the potential for user error due to the reduction of steps that require manual intervention
  • Intuitive technology that requires less training
“Since it is so simple and intuitive, training my techs was a breeze. You could train them in less than an hour. So we were able to cross-train most of the techs in the area in very short time. That makes everything efficient in the laboratory.”
Alexandra Amador, MT (ASCP), CHT (ABHI), Manager
Histocompatibility Lab, University of Miami.

Watch the videos on how AQUIOS CL works on www.AquiosCL.com

AQUIOS CL Error Prevention Features

AQUIOS CL employs several features that work to prevent errors throughout the entire workflow:

  • Automated scanning of specimen barcodes
  • The specimen ID is automatically tracked throughout the run
  • Barcoded reagents
  • Bidirectional connection to the Lab Information System (LIS)
  • Blood aspiration detection
  • Flow cell clogging prevention
  • Volumetric absolute counting without beads
  • Quality control checks for every sample

Download the Product Bulletin: Error Prevention on the AQUIOS CL System for the Tetra Application

AQUIOS CL Provides a 24/7 Flow Cytometry Service

AQUIOS CL can help setting up a 24/7 Flow Cytometry service by…

  • Providing a flow cytometry platform that can be run by less experienced operators
  • Build-in error prevention features throughout the entire workflow
  • Barcode scanning and LIS connectivity that prevent intermixing of samples and/or reagents
  • Auto-gating features in the software
  • Reduced training effort

AQUIOS CL Cleaning Procedures 

  • For a complete overview of all cleaning procedures, please refer to CHAPTER 10, Cleaning Procedures, of the AQUIOS CL User Manual (PN B21896).

    AQUIOS CL Cleaning Procedures
    AQUIOS CL Cleaning Procedures
    AQUIOS CL Cleaning Procedures
    AQUIOS CL Cleaning Procedures
  • At any time, it is possible to trigger a 5-minute cleaning routine involving AQUIOS Sodium Hypochlorite Solution. See “Run Bleach Cycle” in CHAPTER 8, Setup, of the AQUIOS CL User Manual.
  • Cleaning the Wash Station:
    • Open the reagent door
    • Using a cotton swab, dispense enough AQUIOS Sodium Hypochlorite solution to wet the swab without saturating it.
    • Wipe the stainless steel opened portion of the wash station, including the well and rim, with the swab.
  • Cleaning the Barcode Reader on the front of the instrument:
    • Carefully wipe the barcode reader window with a soft, lint-free tissue containing isopropyl alcohol.
    • Verify that the barcode reader is able to scan the reagent information.
  • Cleaning Blood spills:
    • Disinfect the area using a disinfectant solution according to your laboratory’s procedures.
    • Dispose of all materials in your laboratory’s biohazard waste containers.
    • Refer to CLSI/CCCLS document GP17 -Clinical Laboratory Safety for additional information.
  • Cleaning the System:
    • Using wipes soaked with 10% bleach or sporicidin, clean the external surfaces of the instrument.
    • If build up of dried blood is noticed in the probe wash station to the right of the reagent carousel, use a cotton swab soaked with 10% bleach or sporicidin to clean it.
    • Check the wash station overflow tray for spills during routine maintenance and after a wash station overflow and clean if necessary, to prevent any biohazardous contamination.

Spotlight Icon Technical Documents

 

Access Technical Documents here

AQUIOS CL Waste Management

  • Installing the Waste container:
    • Before placing the waste container on the Supply Cart, add 1L of high-quality, fragrance-free, gel-free bleach (5 to 6% solution of sodium hypochlorite -available chlorine) to the empty 10L waste container.
  • Discarding the used 96 well Plate:96 well plates for Aquios CL
    • Before removing the 96 well plate from the instrument, cover the plate with a fitting plate lid.
    • Plate lids can be obtained from your local laboratory equipment provider.

Handle laboratory waste like potentially biohazardous waste according to your laboratory’s policies.



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