Cydem VT Automated Clone Screening System
The Cydem VT Automated Clone Screening System combines multiple trusted Beckman Coulter Life Sciences technologies into one advanced platform that empowers lab managers with a far more effective, higher-throughput method for pool and clone screening in Cell Line Development—offering increased confidence that promising clones don’t get overlooked in the process of consistently selecting the best.
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Features of the Cydem VT Automated Clone Screening System
Combining multiple Beckman Coulter technologies into a single, standalone platform, the Cydem VT Automated Cell Culture System opens up a whole new world to hard-working lab managers and scientists, who strive daily for success in the high-pressure world of Cell Line Development. Gain more understanding from more clones/minipools from one single experiment.
Integrated Bioreactor Module
- Cultivate 96 cultures in parallel in 24-deep well bioreactor plates
- Unique gassing chip for well-individual gassing control
- Maintain optimal pH and DO levels in your cultivations
- Active temperature control
Integrated Cell Count and Viability Module
- Regular updates of cell count and viability throughout your entire experiment
- Accurate and precise measurements with low sample volume
- Utilizes our well-known Vi-CELL BLU Analyzer technology
Integrated Titer Module
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Regular antibody titer measurements
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Learn more about the productivity of your clones/minipools
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Make informed decisions about your clone/minipools selection
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Small sample volume
High Throughput
96 x 5 mL parallel microbioreactors
Optimized Selection Confidence
pH-controlled, fed-batch conditions with individual gassing regulation (CO2 & dissolved oxygen) in each parallel microbioreactor
Early Insights
Regular on-deck cell count, viability and titer measurements throughout the entire cultivation
Full Automation
Less manual work and human error;
reduced risk of contamination
3-Day Walk-Away Automated Operation with Auto-Normalization of Cell Density
- Fully integrated solution with on-deck cell count, cell viability, mAbs titer, pH, and DO measurement
- 3-day walk-away automated operation
- Automated seeding of cell cultures
- Schedule builder for analytical measurements, feeding strategy, and pH control
- Centralized data on one instrument with the ability to easily export in .csv format
- Single point of contact for sales, service, and technical support for the entire system, consumables, and reagents
Clone screening of 96 clones over 14 days. Viable cell density and mAbs titer displayed over the course of the experiment. For a better overview, 10 clones with different growth and productivity performances were selected.
Resources
Introducing the Cydem VT System: A high-throughput platform for fast and reliable clone screening in CLD
Efficient clone screening with increased process control and integrated cell health and titer measurements with the Cydem VT Automated Clone Screening System
Reagents and Consumables
Human IgG Standard Kit, 10 mg
The Human IgG Standard Kit contains 10 mg human IgG standard for measuring a monoclonal antibody (mAb) standard curve with the Cydem VT system.
Cydem VT System Cell Health Test Kit
The Cell Health Test Kit contains reagents for 6 x 96 cell health tests (including Trypan Blue Dye, Cleaning Solution, and Cell Health Diluent). It is recommended if more cell count and viability measurements are required than are included in the regular Cell Culture Standard Experiment Kit.
Product not for use in diagnostic or therapeutic procedures.
Cydem VT System IgG Titer Standard Experiment Kit
The IgG Titer Standard Experiment Kit contains all reagents and titer plates required for a 2-week standard campaign: contains one Human IgG Standard Kit, 10 mg, and two Titer Test Kits (including Titer Diluent, Cleaning Agent, and Titer Plates) for a total of 10 x 96 antibody titer tests.
Product is not intended or validated for use in the diagnosis of disease or other conditions.
Cydem VT System IgG Titer Extended Experiment Kit
The IgG Titer Extended Experiment Kit contains all reagents and titer plates required for an extended campaign: Contains one Human IgG Standard Kit, 10 mg, and three Titer Test Kits (including Titer Diluent, Cleaning Agent, and Titer Plates) for a total of 15 x 96 antibody titer tests.
Product is not intended or validated for use in the diagnosis of disease or other conditions.
| Specifications | Description |
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| Combined size (As installed - Instrumentation, HEPA filter, Workstation cart with monitor)* |
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| Instrument chassis (Cydem VT liquid handler) |
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| Workstation cart size** |
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| Weight (As installed - Instrumentation, HEPA filter, Workstation cart with monitor) |
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*Monitor and mounting arm positioned at a 45° angle.
**Workstation cart is always included in the Cydem VT system.
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Front View 
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Side View 
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Front View Open 
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Explore Cydem VT Models
Technical Documents
Valita, Valita Titer and the ValitaCell logo are trademarks of ValitaCell Ltd in the United States and other countries. ValitaCell is a Beckman Coulter Company.
For Research Use Only. Not for use in diagnostic procedures.
FAQ on the Cydem VT Automated Clone Screening System
What is the throughput of the Cydem VT system?
The Cydem VT Automated Clone Screening System can screen up to 96 clones in parallel shaken 5 mL microtiter plate format.
Which types of monoclonal antibodies (mAbs) can the Cydem VT system detect?
The Cydem VT system uses Valita Titer Assay technology and can quantify all Fc-containing molecules (e.g., IgG-based antibodies IgG 1, 2, 3, and 4 subclasses, standard, bispecific, fusion protein formats, etc.).
What parameters does the Cydem VT system measure during clone and minipool screening?
The system provides regular on-deck measurements of pH and dissolved oxygen (DO) values, monoclonal antibody (mAb) titer, and cell count and viability.
What cultivation modes does the Cydem VT system support?
The Cydem VT system allows for a pH-controlled fed-batch cultivation for 96 clones, with well-specific gassing control for pH (CO2) and dissolved oxygen (DO) control. The liquid handler can add liquid base for additional pH control.
What cell lines does the Cydem VT system support?
The Cydem VT system supports the shaken cultivation of Chinese Hamster Ovary (CHO) cells.
What is the working volume of the Cydem VT system bioreactor plates?
The working volume is in a range of 3-5 mL.
