Application Notes

The real-world benefits provided by our technologies are realized only through their application. 

Our growing repository of application notes runs the gamut of topics—from cutting-edge research on genomic and biopharmaceutical therapies to total organic carbon analysis for modern water systems.

Content and Resources

ICH Q2 – the Challenge of Measuring Total Organic Carbon in Modern Pharmaceutical Water Systems <span style="color: #4d4d4d;">Total Organic Carbon (TOC) is one of the quality attributes defined in the European and USA pharmacopoeias for pharmaceutical waters</span><span style="color: #4d4d4d;">. Modern water treatment systems can deliver such high purity water that TOC levels can be consistently close to zero and very difficult to measure with any accuracy. This paper discusses some of the challenges when using TOC analysers to demonstrate pharmacopoeial TOC level compliance for modern water systems in the light of the ICH Q2 document</span><span style="color: #4d4d4d;">2</span><span style="color: #4d4d4d;">&nbsp;from the International Conference on Harmonisation.</span>
Aerobic cultivation of high-oxygen-demanding microorganisms in the BioLector XT microbioreactor
Anaerobic cultivation processes of probiotic bacteria in the BioLector XT microbioreactor
Analyzing Mussel/Mollusk Propagation using the Multisizer 4e Coulter Counter
Temperature dependence of hydrodynamic radius of an intrinsically disordered protein measured in the Optima AUC analytical ultracentrifuge. Analytical ultracentrifugation experiments over a wide range of temperatures were conducted to measure the hydrodynamic radius of an intrinsically disordered protein. Taking advantage of the highly stable temperature control offered through the latest shroud modification available in the new Optima AUC, replicate experiments demonstrated highly reproducible hydrodynamic parameters that suggest slight changes in the hydrodynamic radius of an intrinsically disordered protein, and impressive performance in both temperature control and data quality from the Optima AUC.

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