Nanoparticle Research

Leverage the power of flow cytometry for the detection and characterization of cellular origin nanoparticles

Interest in nanoparticles of cellular origin is exploding due to new insights into the role these particles play in extracellular communication processes and the potential for detecting pathological states via liquid biopsy.

Several fundamental capabilities of flow cytometry make this an attractive platform for extracellular vesicle research, such as the ability to detect large numbers of events and discriminate rare events while collecting information on surface composition.

Recent developments in laser and electronics design pushed the boundaries of reliably detecting events in the nanoparticle size range. The CytoFLEX Flow Cytometer is the first benchtop instrument with acceptable noise-to-signal discrimination for the reliable detection of particles down to 80 nm. 

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Looking Under the Hood: Getting Started with the Optima AUC In the webinar we discuss the fundamentals of analytical ultracentrifugation and look at a few sample applications.
Webinar: An Intro to Characterization of Biomolecules Using AUC Analytical Ultracentrifugation (AUC) is one of the most powerful biophysical tools used today for the characterization of biological samples ranging from small drug molecules to intact viruses, vesicles and microparticles
Analytical Ultracentrifugation in Nanoparticle Analysis Joshua Robinson covers the utility of fractionation in the investigation of complex mixtures and polydisperse samples as well as versatility of analytical ultracentrifugation (AUC) for colloid chemistry. He quickly reviews analytical ultracentrifugation (AUC) theory, then discusses deconstructing nano-constructs and how AUC has been used in recent literature to really probe the underlying structure of nano-constructs, nanomaterials. Other topics covered include nanoparticle sample preparation, as well as Beckman Coulter's research and future perspectives.
Extracellular Vesicles for ‘Liquid Biopsy’ Development in Cancer by Dr. Karla Williams Using nano-scale flow cytometry, the Williams lab has identified a secondary bio-marker that allows them to identify the most critical prostrate cancer in patient samples. This revolutionary discovery has the potential to reduce unnecessary needle biopsy surgeries because only a blood sample is needed, as well as reduce overall costs to test for the disease. The Williams lab expects to move to clinical trial phase in the coming months. 
Physical and Chemical Characterization of Nanoparticle Constructs Using the Analytical Ultracentrifuge Webinar covers physical and chemical characterization of nanoparticle constructs using analytical ultracentrifugation. Webinar is presented by Osman M Bakr from King Abdullah University of Science and Technology. 

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