Error Prevention at Start Up, Cleaning and Worklist Generation
The AQUIOS CL system employs several features that work to prevent errors during startup, cleaning, and worklist generation. These prevention methods can be broken down into the following:
Table 2. Error Prevention Startup/Cleaning/Worklist Generation at a Glance
Autocleaning
Autocleaning is a function integrated directly into the AQUIOS system. The AQUIOS CL flow cytometer continually monitors and detects potential clogs and/or air bubbles in the flow cell. Upon detection of a potential clog or bubble in the flow cell, the system aborts the sample run and activates an autocleaning cycle. Once this cycle is complete, the system will rerun the aborted sample. Autocleaning reduces the potential for low precision and erroneous results. In addition, autocleaning reduces the need for sample reruns.
Test Requests to and from the LIS
Traditional flow cytometers do not automatically transfer test requests to and from the LIS without the added expense of middleware. If the LIS connection is enabled on the AQUIOS CL flow cytometer, the system automatically retrieves the test request from the LIS. Users with Reviewer access are authorized to review and transmit samples to the LIS. Reviewer users are able to generate and perform test requests, and review and release results.
Not only does the built-in LIS ensure automatic transfer of test requests reducing transcription errors, but no middleware is required. Different user access levels ensure that operators can only work on areas that align with their level of experience with the system.
Creating Worklists
On a traditional flow cytometer, there is no direct connection from the worklist to sample preparation system, or sample preparation system to the analyzer. Traditional flow cytometers automatically send the results from the analyzer to the LIS and the test request from the middleware to the analyzer when using middleware. Potential errors may result because everything is not linked together. Refer to Figure 1 for a visual representation of an LIS connection using the FC 500 flow cytometer and TQ-Prep sample prep system.
Figure 1. LIS Connection for FC 500 Flow Cytometer and TQ-Prep Sample Prep System
Conversely, the AQUIOS CL flow cytometer is one seamless system; no middleware is required. However, middleware can be used if desired. The system is able to send test requests to the analyzer and capture the information to automatically generate a worklist. Refer to Figure 2 for a visual representation of the LIS connection for the AQUIOS CL flow cytometer.
Figure 2. LIS Connection for the AQUIOS CL Flow Cytometer
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