Viral Particle Purification Using Centrifugation Methods
High-resolution isolation and purification of intact viral particles and plasmids encoding virus/vaccine production through Beckman Coulter's centrifugation product line.
Fundamentals of Virus Purification - Professor Dr. Osamu Nakagomi's interview describing his research and expertise with the molecular epidemiology of the rotavirus and how ultracentrifugation plays a key role in the purification of viruses.
From basic research to biologics production, viral systems play an important role in the large-scale production of recombinant proteins. The production and purification of viral particles is a multi-step process that needs to be carefully optimized to maximize viral titers and protein yield.
Dr. Ross VerHeul explores the gold standard for high resolution density-based separations, Density Gradient Ultracentrifugation (DGUC) in this spINSIGHTS from the lab.
3rd Party Reference Publications
- Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
- Conformational reorganization of the SARS coronavirus spike following receptor binding: implications for membrane fusion.
- Indomethacin has a potent antiviral activity against SARS CoV-2 in vitro and canine coronavirus in vivo
- Modern uses of electron microscopy for detection of viruses.