HLA-DR-SNv786, Immu-357, 50 Tests, RUO

Product No:C78087

The human major histocompatibility complex (MHC), also called human leucocyte antigens (HLA), is composed of three groups of molecules designated MHC class I, class II and class III. The MHC class II genomic region, or HLA-D region, contains the genes encoding HLA-DR, -DQ and -DP antigens. The MHC class II molecules are built by the non-covalent association of α/β heterodimers. Both heavy (α) and light (β) chains span the cell membrane. They have molecular weights of 31-33 kDa and 26-29 kDa respectively. HLA-DR molecules are found on antigen-presenting cells (APC), i.e. dendritic cells, B lymphocytes, monocytes, macrophages, Langerhans cells and thymic epithelial cells. They are also expressed on activated T cells, but not on granulocytes, platelets, or red blood cells. Resting T cells or endothelial cells that do not normally express these molecules can be induced to express them. HLA-DR is also expressed on some hematopoietic progenitor cells at different stages of differentiation.

Product Specifications

Format Liquid
Specificity HLA-DR
Form SNv786
Clone Immu-357
Isotype IgG1 Mouse
Cross Reactivity Capuchin Monkey, Cotton-topped Tamarin, Cynomolgus Monkey, Hamadyras Baboon, Indian Rhesus, Olive Baboon
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced C78087

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