CD4-APC, 13B8.2, 1 mL, ASR

Product No:IM2468U

The CD4 antigen is a single-chain transmembrane glycoprotein with a 59 kDa molecular weight. CD4 binds to a non-polymorphic region of MHC Class II molecules and is a co-receptor in MHC Class II restricted antigen-induced activation. CD4 is expressed on the T "helper" lymphocytes. It is present on most thymocytes where it is frequently co-expressed with CD8. CD4 is also expressed on all monocytes, although with a lower density than on T lymphocytes. CD4+ T lymphocytes are active in inducing and helping the synthesis of immunoglobulins by B cells. CD4 is a receptor for the Human Immunodeficiency Virus type I (HIV-1) envelope protein gp120.

Product Specifications

Target Species Human
Specificity CD4
Other Names CD4, T4 antigen
Fluorochrome APC
Regulatory Status ASR
Size 1 mL
Format Liquid
Flow Product Line IOTest
Clone 13B8.2
Isotype IgG1 Mouse
Clone Description 13B8.2 monoclonal antibody antagonizes HIV effects in vitro. 13B8.2 recognizes an epitope close to the amino-acid residues 88-89 within the CD4 molecule. 13B8.2 and BL4 recognize different epitopes. 13B8.2 and BL4 are not cross-blocking.
Cross Reactivity Hamadyras Baboon, Olive Baboon

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