CD4 Antibodies
The CD4 antigen is a monomeric transmembrane glycoprotein with a molecular weight of 59 kDa. The intracytoplasmic tail of CD4 is essential for interaction with Lck. The CD4 is expressed on the T "helper" (Th or T4) lymphocytes. It is expressed on most thymocytes, where it is frequently co-expressed with CD8. CD4 is also expressed on eosinophils. All the monocytes carry the CD4 antigen, but at a lower density than T4 lymphocytes. CD4 acts as an accessory molecule to the T cell receptor complex during T-cell activation restricted to the major histocompatibility complex class II. The T4 lymphocytes are involved in T-T, T-B, and B-macrophage cellular interactions. They are active in inducing and helping the synthesis of immunoglobulins by B cells. CD4 functions as the receptor for IL-16 which is a chemoattractant factor for CD4+ T cells, as well as for monocytes and eosinophils. IL-16 seems to be a growth factor for T4 lymphocytes, but is not able to induce cell division. CD4 is a receptor for the Human Immunodeficiency Virus type I (HIV-1) envelope protein gp120.
Clone: 13B8.2 | Isotype: IgG1 Mouse |
13B8.2 monoclonal antibody antagonizes HIV effects in vitro. 13B8.2 recognizes an epitope close to the amino-acid residues 88-89 within the CD4 molecule. 13B8.2 and BL4 recognize different epitopes. 13B8.2 and BL4 are not crossblocking. |
Clone: SFCI12T4D11 | Isotype: IgG1 Mouse |
SFCI12T4D11 monoclonal antibody antagonizes HIV effects in vitro. |
Choose a CD4 Model
Product Line Specifications
Format | Liquid |
Specificity | CD4 |
Form | PC5.5 |
Clone | 13B8.2 |
Isotype | IgG1 Mouse |
Cross Reactivity | Hamadyras Baboon, Olive Baboon |
Target Species | Human |
Flow Product Line | IOTest |
Item Specifications Referenced | B16491 |
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.