CD37 Antibodies

The CD37 antigen is a 40-52 kDa single chain transmembrane protein with 4 transmembrane domains (Tetraspan/TM4SF). It has both its NH2‑ and COOH-termini inside the cells, and is heavily glycosylated on one extracellular loop. Its main feature is its high content of hydrophobic residues (45%). CD37 is strongly expressed on the surface of human peripheral blood B lymphocytes and on B cells from germinal centers. In the ontogeny of B cells, this antigen appears late, after the pre‑B stage, and is not expressed on plasma cells. CD37 has a low expression on T lymphocytes, granulocytes, and monocytes. It is weakly expressed by other cellular types such as Langerhans cells, macrophages, normal medullar granulous cells and peripheral blood polymorphonuclear cells. CD37 is involved in signal transduction.

Clone: BL14 Isotype: IgG1 Mouse

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