CD366 (TIM-3)-SNv428, F38-2E2, 50 tests, RUO

Product No:C74033

CD366 also known as TIM-3 (T-cell immunoglobulin and mucin containing protein-3) is a type I transmembrane protein that in humans is encoded by the HAVCR2 gene. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. TIM-3 acts as a negative regulator of Th1/Tc1 function by triggering cell death upon interaction with its ligand, galectin-9. TIM-3 is also known to be expressed on certain innate immune cells, including NK cells, macrophages, DCs, and mast cells. TIM-3 plays an important role in immunity, the dysregulation of TIM-3 expression has been associated with autoimmune diseases, viral infections and cancer and it’s expression on numerous cell types (T cell, Treg, dendritic cell, myeloid cells) favors tumor escape to immune cells.

$565.00 List Price - $565.00


Product Specifications

Target Species Human
Specificity CD366 TIM-3
Other Names Tim-3, Tim3
Fluorochrome SNv428
Regulatory Status RUO
Size 50 Tests
Format Liquid
Flow Product Line IOTest
Clone F38-2E2
Isotype IgG1 Mouse
Volume 0.5 x mL

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