The CD35 antigen is a polymorphic molecule. Different molecular weights: 160, 190, 220, 250 and 285 kDa were reported for the various allotypes. It is known as the complement receptor type I (CR1) with affinity for C3b, C4b and iC3b. The CD35 antigen is expressed by granulocytes (except basophils), B lymphocytes, a subset of T-cells, monocytes, some NK cells, erythrocytes macrophages cultured in vitro, glomerular podocytes and follicular dendritic cells. The CD35 antigen mediates phagocytosis by neutrophils and monocytes of complement coated particles.
|Clone: J3D3||Isotype: IgG1 Mouse|
|The J3D3 monoclonal antibody inhibits CR1-mediated decay of cells bound to the alternative and classical pathways to C3-convertase sites. It also inhibits C3b dependent rosette formation with lymphocytes.|