CD3-RD1, UCHT1, 100 Tests , CE, IVD

CD3ζ see TCRζ in Human non-CD antigens section. The CD3 antigen is a complex of 5 invariable polypeptidic chains, γ, δ, ε, ζ and η, whose molecular weights are respectively 25-28, 21, 20, 16 and 22 kDa. The ζ chain occurs in the CD3 complex as a disulphide linked homodimer or as a heterodimer with the η chain. CD3 is part of a bigger complex which includes the T Cell Receptor (TCR). This complex is expressed by mature T cells and by thymocytes. T cell activation may be induced when a foreign antigen is presented to the TCR through MHC complex.