CD3 Antibodies

The CD3 antigen is a complex of 5 invariable polypeptidic chains: γ, δ, ε, ζ and η, whose molecular weights are respectively 25-28, 21, 20, 16 and 22 kDa. The CD3 chains are clustered in a group of two invariant dimers, γ/ε and δ/ε associated with a variable dimer which consists of ζ homodimers, or ζ /η, or ζ/γ FcR heterodimers (γ FcR being the γ chain of the Fc receptors), or γFcR homodimers. The CD3 is part of a bigger complex which includes the T Cell Receptor (TCR). CD3 complex associated with the TCR is involved in the recognition of peptides bound to the major histocompatibility complex class I and II during the immune response. T cell activation may be induced when a foreign antigen is presented to the TCR through MHC complex. The CD3 antigen is expressed by mature T lymphocytes and by a subset of thymocytes.

CD3ζ see TCRζ.

Clone: UCHT1 Isotype: IgG1 Mouse

UCHT1 reacts with the ε-chain of the CD3 complex. It was used as a CD3 reference mAb (ref.6T-CD3.1) during HLDA 6. After permeabilization with saponin-based permeabilization reagent IntraPrep, it may be used to detect intracytoplasmic CD3 by flow cytometry.

Explore CD3 Antibodies

Product Line Specifications

Format Liquid
Specificity CD3
Form APC-Alexa Fluor* 700
Clone UCHT1
Isotype IgG1 Mouse
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced B10823

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 

Technical Documents