CD25 Antigen

The CD25 antigen (IL-2Rα chain, Tac or p55) is a single-chain glycoprotein with a molecular weight of 55 kDa which is the low affinity receptor for IL-2 (IL-2Rα or IL-2R1). In conjunction with CD122 (IL-2Rβ, p75) and CD132 (IL-2Rγ, p64), CD25 antigen forms the high-affinity IL-2R complex. CD25 is highly expressed on regulatory CD4-positive T lymphocytes and undetected on resting CD8 positive lymphocytes. However, all activated T lymphocytes express the CD25 protein. CD25 is also found on a subset of B cells (CD20 positive), on activated monocytes and macrophages, and on T cell clones. It is also expressed on NK cells enriched from peripheral blood lymphocytes by culturing in the presence of IL-2. It is absent from thymocytes, granulocytes, monocytes, resting NK cells, platelets and erythrocytes.


Clone: 1HT44H3 (IL-2R1)  Isotype: IgG2a Mouse

Clone: B1.49.9 Isotype: IgG2a Mouse

The B1.49.9 monoclonal antibody does not block the binding of IL-2 to its receptor.

Choose a CD25 Model

Product Line Specifications

Format Liquid
Specificity CD25
Form APC-Alexa Fluor* 750
Clone B1.49.9
Isotype IgG2a Mouse
Cross Reactivity Mink, Ovine, Squirrel Monkey
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced B13979

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


Technical Documents