CD243 (P-glycoprotein) Antibodies

The CD243 antigen (P-gp) is the 170-180 kDa multi-drug resistance (mdr)-1 gene product. This protein carries out ATP-dependent efflux of structurally diverse lipophilic compounds, including many anti-cancer chemotherapy agents. In hematopoietic cells, the mdr1 gene product is expressed, but at relatively low levels. P-gp is expressed in specialized epithelial cells with secretory or excretory functions. In the liver, P-gp is found on the biliary surface of hepatocytes and small biliary ductules; in the pancreas, on the laminal surface of epithelial cells of small ductules and, in the kidney, on the brush border of the proximal tubules. Additional sites of expression include the gastrointestinal tract, endothelial cells of the brain and the adrenal glands.

Clone: UIC2 Isotype: IgG2a Mouse

The UIC2 antibody reacts with an external epitope of the human P-glycoprotein (P‑gp). UIC2 antibody inhibits P-gp mediated efflux and potentiates the cytotoxic action of P-gp transported drugs in MDR cells.

Explore CD243 Models

Content and Resources

SuperNova v428: New Bright Polymer Dye for Flow Cytometry Applications In this paper you will discover the latest generation of polymer dyes for flow cytometry applications – SuperNova fluorochromes.
CD Chart CD Chart
CE-IVD Single Color Antibodies (OUS version) CE-IVD Single Color Antibodies (OUS version)
Clinical Single Color Antibodies (US version) Clinical Single Color Antibodies (US version)
7 Tips for Multi Color Panel Design Seven Tips for Achieving the Perfect Panel for Multicolor Flow Cytometry