The CD2 antigen (also called LFA-2 or T11 antigen) is a 50 kDa single chain type I transmembrane glycoprotein that comprises two external domains belonging to the immunoglobulin superfamily (IgSF). It was formerly described as the sheep red blood cell receptor, causing T-cell rosetting. Signaling molecules, such as Fyn, Lck and the PI3-kinase, have been reported to associate with the intracellular domain of CD2. CD2 has been identified as the ligand for CD58 (LFA-3). It is also a receptor for CD48, CD59 and CD15. The CD58-CD2 interaction is a component of intercellular adhesion and costimulatory signaling in T cells. CD2 is involved in the regulation of human T-cell cytokine production, and in a Fas-independent induced apoptosis of activated human peripheral T cells. CD2 is present on all human non-B peripheral lymphocytes, on the majority of thymic T cells, and on a subset of thymic B cells.
|Clone: SFCI3Pt2H9 (T11)||Isotype: IgG1 Mouse|
|SFCI3Pt2H9 inhibits sheep erythrocyte rosette formation. It has been used as a CD2 reference monoclonal antibody during HLDA 6 (ref.6T-CD2.6).|
|Clone: 39C1.5||Isotype: IgG2a Rat|
|39C1.5 inhibits sheep erythrocyte rosette formation. It has been used as a CD2 reference monoclonal antibody during HLDA 6 (ref 6T-CD2.7).|
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Product Line Specifications
|Form||APC-Alexa Fluor* 700|
|Cross Reactivity||Cynomolgus Monkey, Hamadyras Baboon, Indian Rhesus, Capuchin Monkey, Common Marmoset, Equine, Olive Baboon, Squirrel Monkey|
|Flow Product Line||IOTest|
|Item Specifications Referenced||B12111|
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.