The beta2 integrins (CD11/CD18) are the major adhesion molecule family of leukocytes. Most leukocytes express one or more members of this family. CD18 is the 95 kDa integrin β2-chain which forms non-covalently-bound heterodimers with one of four α subunits. The four alpha subunits are: CD11a (αL) (all leukocytes), CD11b (αM) (granulocytes, monocytes, some macrophages), CD11c (αX) (granulocytes, monocytes, dendritic antigen presenting cells), CD11d (αD) (CD8 T-cell subpopulation including large granular lymphocytes, macrophages and gamma-delta T cells in splenic red pulp). CD18 is expressed by all leukocytes (including histiocytes - macrophages, Langerhan's cells and dendritic cells) but no platelets. Macrophages and granulocytes express 10-fold more CD18 than do lymphocytes.
|Clone: 7E4||Isotype: IgG1 Mouse|
|7E4 is a blocking monoclonal antibody in cell adhesion assays.
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Product Line Specifications
|Cross Reactivity||Cynomolgus Monkey, Indian Rhesus, Hamadyras Baboon, Olive Baboon, Ovine, Bovine, Porcine, Equine, Canine, Feline, Mink, Llama|
|Flow Product Line||IOTest|
|Item Specifications Referenced||IM1570U|
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.