CD16-PC5, 3G8, 1 mL, ASR

IM2642U

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The CD16 antigen is the low-affinity receptor for IgG (FcγRIII). The CD16 antigen exists in two different forms encoded by two different genes: FcγRIIIA (or III-2) and FcγRIIIB (or III-1). The genetic heterogeneity of CD16 generates alternative membrane-anchored molecules. One is a transmembrane form (FcγRIIIA, 50-65 kDa) expressed on NK cells, monocytes and macrophages. The other is a glycosylphosphatidylinositol (GPI)-anchored form (FcγRIIIB, 48 kDa) only expressed on neutrophils. It has been shown that the CD16 antigen can be non-covalently associated within the membrane of NK cells, to a disulfide-linked homo or heterodimer made from the 16 kDa CD3ζ chain and the FcεRIγchain.

Specifications

Target Species Human
Specificity CD16
Other Names CD16, Fc gamma R IIIa&b, FCγRIII, FcγRIIIA/IIIB
Fluorochrome PC5
Regulatory Status ASR
Size 1 mL
Format Liquid
Flow Product Line IOTest
Clone 3G8
Isotype IgG1 Mouse
Clone Description The 3G8 monoclonal antibody is inappropriate for western Blot use. 3G8 binds to both isoforms of the CD16 molecule.
Cross Reactivity Cynomolgus Monkey, Indian Rhesus, Hamadyras Baboon, Olive Baboon, Capuchin Monkey, Common Marmoset, Equine, Canine, Squirrel Monkey


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The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.