CD16-PC5, 3G8, 1 mL, ASR
Product No:IM2642U
The CD16 antigen is the low-affinity receptor for IgG (FcγRIII). The CD16 antigen exists in two different forms encoded by two different genes: FcγRIIIA (or III-2) and FcγRIIIB (or III-1). The genetic heterogeneity of CD16 generates alternative membrane-anchored molecules. One is a transmembrane form (FcγRIIIA, 50-65 kDa) expressed on NK cells, monocytes and macrophages. The other is a glycosylphosphatidylinositol (GPI)-anchored form (FcγRIIIB, 48 kDa) only expressed on neutrophils. It has been shown that the CD16 antigen can be non-covalently associated within the membrane of NK cells, to a disulfide-linked homo or heterodimer made from the 16 kDa CD3ζ chain and the FcεRIγchain.
$660.10 List Price - $660.10
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Product Specifications
| Target Species | Human |
| Specificity | CD16 |
| Other Names | CD16, Fc gamma R IIIa&b, FCγRIII, FcγRIIIA/IIIB |
| Fluorochrome | PC5 |
| Regulatory Status | ASR |
| Size | 1 mL |
| Format | Liquid |
| Flow Product Line | IOTest |
| Clone | 3G8 |
| Isotype | IgG1 Mouse |
| Clone Description | The 3G8 monoclonal antibody is inappropriate for western Blot use. 3G8 binds to both isoforms of the CD16 molecule. |
| Cross Reactivity | Cynomolgus Monkey, Indian Rhesus, Hamadyras Baboon, Olive Baboon, Capuchin Monkey, Common Marmoset, Equine, Canine, Squirrel Monkey |