CD16 Antigen
The CD16 antigen is the low-affinity receptor for IgG (FcγRIII). The CD16 antigen exists in two different forms encoded by two different genes: FcγRIIIA (or III-2) and FcγRIIIB (or III-1). The genetic heterogeneity of CD16 generates alternative membrane-anchored molecules. One is a transmembrane form (FcγRIIIA, 50-65 kDa) expressed on NK cells, monocytes and macrophages. The other is a glycosylphosphatidylinositol (GPI)-anchored form (FcγRIIIB, 48 kDa) only expressed on neutrophils. It has been shown that the CD16 antigen can be non-covalently associated within the membrane of NK cells, to a disulfide-linked homo or heterodimer made from the 16 kDa CD3ζ chain and the FcεRIγchain.
| Clone: 3G8 | Isotype: IgG1 Mouse |
| The 3G8 monoclonal antibody is inappropriate for western blot use. 3G8 binds to both isoforms of the CD16 molecule. | |
Choose a CD16 Model
Product Line Specifications
| Format | Liquid |
| Specificity | CD16 |
| Form | APC-Alexa Fluor* 700 |
| Clone | 3G8 |
| Isotype | IgG1 Mouse |
| Cross Reactivity | Cynomolgus Monkey, Indian Rhesus, Hamadyras Baboon, Olive Baboon, Capuchin Monkey, Common Marmoset, Canine, Equine, Squirrel Monkey |
| Target Species | Human |
| Flow Product Line | IOTest |
| Item Specifications Referenced | B20023 |
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.