CD158i Antibodies

The CD158i molecule (also known as p50.3) is a monomeric integral membrane glycoprotein of 50 kDa. This protein belongs to the family of NK receptors for MHC class I molecules. There is another comprehensive nomenclature which refers to this molecule as KIR2DS4; this acronym stands for Killer cell Immunoglobulin (Ig)-like Receptor (KIR), with extracellular part containing 2 Ig domains (2D), and a short (S) cytoplasmic tail. CD158i comprises 2 C-type extracellular Ig domains. The intracytoplasmic portion lacks characteristic ITIM motifs (Immunoreceptor Tyrosine-based Inhibition Motif) and displays a charged residue in the trans-membrane portion. CD158i receptor seems involved in NK cell activation, following HLA-Cw3 supertype recognition. Antibody-induced cross-linking of CD158i (p50.3) results in both early activation events and late effector function.


Clone: FES172 Isotype: IgG2a Mouse

The FES172 antibody stains NK subsets, but the p50.3 antigen appears to be expressed only by some individuals, and to be co-expressed with p58 KIRs.

Explore CD158i Antibodies

Content and Resources

Building IVDR-compliant panels for haematological disorders Diagnostic purpose of the IVDR conjugated antibodies
Building IVDR compliant panels for haematological disorders wallchart Diagnostic purpose of the IVDR conjugated antibodies
Building IVDR compliant panels for haematological disorders wallchart Diagnostic purpose of the IVDR conjugated antibodies
CE-IVD Single Color Antibodies (OUS version) CE-IVD Single Color Antibodies (OUS version)