CD152 (CTLA-4) Antigen
The CD152 antigen, also called CTLA4, is an integral membrane protein belonging to the immunoglobulin superfamily, which is expressed either as a 30 kDa monomer or as a disulfide-linked homodimer. It has homology with the T cell antigen CD28, and like CD28, is a ligand for CD80 and CD86. CTLA-4 is transiently expressed by activated T cells and is not detectable in resting T cells. CD152 and CD28 are involved in the costimulation required for T cell activation. CD152 is an essential checkpoint control for autoimmunity; however, the molecular mechanism(s) by which CTLA-4 achieves its regulatory function are not well understood, especially how it functionally intersects with the CD28 pathway.
|Clone: BNI3||Isotype: IgG2a Mouse|
|The BNI3 antibody can be used to detect intracytoplasmic CD152 (CTLA4) by flow cytometry after permeabilization with IntraPrep Permeabilization Reagent.|
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Product Line Specifications
|Cross Reactivity||Cynomolgus Monkey, Indian Rhesus, Chimpanzee, Olive Baboon, Ovine, Porcine|
|Flow Product Line||IOTest|
|Item Specifications Referenced||IM2282|
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.