CD141 (BDCA-3) Antibodies
CD141, also known as thrombomodulin (TM) and BDCA-3, is an endothelial cell surface receptor. It is a 75 kD type I membrane glycoprotein and members of C-type lectin family. Two major isoforms exist, differentiated by the presence or not of sulfated glycosaminoglycan at Ser/Thr region. CD141 antigen is expressed on neutrophils, monocytes and platelets. CD141 is expressed at high levels on a minor subpopulation of human myeloid dendritic cells that show monocytoid morphology. This subpopulation of dendritic cells is of special interest, because it has an influence on regulatory T cells and hence on immune responses. CD141 is also expressed by vascular endothelial cells, and keratinocytes. It is a cofactor in the activation of protein C and initiation of the protein C anticoagulant pathway by binding to its ligand thrombin.
Clone: M80 | Isotype: IgG1 Mouse |
Explore CD141 Antibodies
Product Line Specifications
Format | Liquid |
Specificity | CD141 |
Form | FITC |
Clone | M80 |
Isotype | IgG1 Mouse |
Target Species | Human |
Flow Product Line | IOTest |
Item Specifications Referenced | B43289 |
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.