CD141 (BDCA-3) Antibodies

CD141, also known as thrombomodulin (TM) and BDCA-3, is an endothelial cell surface receptor. It is a 75 kD type I membrane glycoprotein and members of C-type lectin family. Two major isoforms exist, differentiated by the presence or not of sulfated glycosaminoglycan at Ser/Thr region. CD141 antigen is expressed on neutrophils, monocytes and platelets. CD141 is expressed at high levels on a minor subpopulation of human myeloid dendritic cells that show monocytoid morphology. This subpopulation of dendritic cells is of special interest, because it has an influence on regulatory T cells and hence on immune responses. CD141 is also expressed by vascular endothelial cells, and keratinocytes. It is a cofactor in the activation of protein C and initiation of the protein C anticoagulant pathway by binding to its ligand thrombin.

Clone: M80 Isotype: IgG1 Mouse

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Product Line Specifications

Format Liquid
Specificity CD141
Clone M80
Isotype IgG1 Mouse
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced B43289

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 

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