CD137 Antigen
CD137, also known as 4-1BB or ILA (for Induced by Lymphocyte Activation) is a 39kDa type I integral membrane protein of the TNF/NGF family. CD137 is expressed on activated T and B cells, NK cells, monocytes and follicular dendritic cells. Differential splicing leads to the release of a 16-kDa soluble from activated T cells. CD137 is involved in monocyte activation by inducing an increase in the production of IL-6, IL-8 and TNF-α, and an inhibition of IL-10 production. In addition, CD137 plays a role in the induction of B lymphocyte apoptosis and the co-stimulation
of T-cell proliferation.
Clone: 4B4-1 | Isotype: IgG1 Mouse |
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Product Line Specifications
Format | Liquid |
Specificity | CD137 |
Form | ECD |
Clone | 4B4-1 |
Isotype | IgG1 Mouse |
Target Species | Human |
Flow Product Line | IOTest |
Item Specifications Referenced | B76262 |
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.