CD135 (flt3/flk2) Antigen

The CD135 antigen, also called FLT3 or FLK2 or STK1, is an integral transmembrane glycoprotein of 130 kDa to 150 kDa, which belongs to the class III receptor tyrosine kinase (RTK) family. These receptors directly bind extracellular ligands and transduce regulatory signals through intracytoplasmic tyrosine kinase activity. The CD135 antigen is expressed on myelomonocytic and primitive B cell progenitors. On normal bone marrow cells, expression of CD135 can be found on CD34-positive as well as CD34-negative cells. Most of the CD34bright, CD135-positive cells co-express CD117 at high levels. They may represent early cycling, not quiescent stem cells. CD135-positive cells in the CD34 low and CD34-negative populations do not co-express CD117 molecule and may represent B-lymphoid precursors.


 Clone: SF1.340  Isotype: IgG1 Mouse

The SF1.340 antibody is specific for an extracellular domain of CD135. This antibody does not compete with the FLT3 ligand for binding to FLT3.
 

Choose a CD135 Model

Product Line Specifications

Format Liquid
Specificity CD135
Form PE
Clone SF1.340
Isotype IgG1 Mouse
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced IM2234U

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


Technical Documents