The β2-microglobulin is the non-polymorphic non-covalently bound light chain (12 kDa) of the class I major histocompatibility complex (MHC-I) constitutively expressed on the surface of almost all nucleated cell. β2‑microglobulin structure, stabilized by a disulfide bound, is similar to an immunoglobulin like domain. β2‑microglobulin is required in the endoplasmic reticulum (ER) to associate with the MHC class I heavy molecule to form with other proteins (calreticulin, tapasin, etc.) the loading complex that exits the ER and is transported to the cell surface. After peptide presentation, β2-microglobulin is actively released into circulation.
|Clone: B1G6||Isotype: IgG2a Mouse|
|The B1G6 monoclonal antibody is specific for human β2-microglobulin. It does not react with β2-microglobulin from other species. It recognizes the β2-microglobulin, free or associated with human HLA class I molecules.|