Optima AUC

Beckman Coulter introduced the first AUC sample characterization instrument to help the scientific community power new discoveries. That tradition continues into the 21st century with the new Optima AUC system.

This latest tool is the most robust technology for providing data used to determine protein molecular weight in basic protein research and quantification of aggregation levels for academic and biopharma research.

Want to learn more about Analytical Ultracentrifugation?


Improved Data Quality

  • Higher radial resolution
  • Better signal to noise ratio than ProteomeLab
  • 11x more vertical pixels for interference optics
  • Enables precise analysis of complex systems at discrete wavelengths (up to 20) in minimal time

Analyzes a wide array of particles in native, matrix-free conditions, including:

  • Proteins
  • Nanoparticles
  • Peptides
  • Polymers
  • Micelles
  • Liposomes
  • Extracellular vesicles
  • Drug conjugates
  • Viral payload

Provides data which can answer more critical questions than any other comparable technique, including:

  • Shape
  • Mass
  • Diameter
  • Stoichiometry
  • Heterogeneity
  • Association
  • Aggregation
  • Purity
  • Formulation

Easier to Use

  • User-friendly touchscreen display indicates intuitive progression of experimental design.
  • Remote monitoring capabilities let you set up, monitor and extract data from virtually any location.
  • Compatibility with ProteomeLab XL cells and rotors
  • Toggle optics expedite workflow preparation

Explore Optima AUC Models

Product Specifications

Acceleration 5-400 rpm/second (above 500 rpm), 400 max acceleration
Deceleration 5-400 rpm/second (above 500 rpm), 400 (max deceleration)
Speed Control ± actual rotor speed, ± 2 rpm at steady state
Timed Run 1 to 999 hrs, 59 mins (including hold runs)
Max Capacity Volume Range 0 - 0.4 mL
Speed Display 1,000 to rated speed in 100 rpm increments
Temperature Control 0.50 °C of set temperature after equilibration
Temperature Range(s) Ambient temperature range: 10 to 30°C, Set temp: 7-40° C (1°C increments at > 25-30°C ambient temp); 4-40°C (1°C increments at <25°C ambient temp)
Operating System(s) LINUX
Display 15.3" high-resolution color touch screen
Item Specifications Referenced B86436

Content and Resources

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Resource Type
The History of AUC - An Analytical Ultracentrifuge A brief review of highlights in the long history of analytical ultracentrifugation -- from the 1920s through the dawn of the 21st century -- focused on its importance in the fields of science, medicine and industry
Optima AUC Overview, New Analytical Ultracentrifuge A brief overview of some of the features of the Optima AUC analytical ultracentrifuge that make it the most robust research technology available for thorough analysis of proteins, viruses and other macromolecules in their native, matrix-free state
Introduction to AUC - an Analytical Ultracentrifuge A brief but informative visual demonstration of the process of analytical ultracentrifugation, which enables live monitoring of macromolecules in solution under native, biologically relevant conditions
AUC Symposium -&nbsp;Building Better Things with the Analytical Ultracentrifuge Learn from Dr. David J Scott how you can readily apply AUC to your particular systems of choice, what information an AUC can give, and where such an analysis will strengthen your conclusion <p>&nbsp;</p> <p><span class="citation">21.06.1920.CENT</span></p>
AUC Symposium: Characterization of Gene Therapy Formulations by Analytical Ultracentrifugation <p>In this presentation, Amy Henrickson demonstrates analytical ultracentrifugation (AUC) methods, using multi-wavelength (MW) detection and heavy water density matching, to characterize LNP and AAV formulations.</p> <p>&nbsp;</p> <p><span class="citation">21.06.1921.CENT</span></p>

Technical Documents