ROR1, the Receptor tyrosine kinase-like orphan receptor 1, is a member of the ROR receptor family consisting of two closely related type I transmembrane proteins ROR1 and ROR2. RORs are classified as pseudokinases lacking detectable catalytic activity. They are highly homologous in humans and mice. ROR1 and ROR2 are composed of a distinguished extracellular region with one immunoglobulin domain, one frizzled domain, and one kringle domain, followed by a transmembrane region and an intracellular region that contains a tyrosine kinase domain. ROR1 stands out for its selective and high expression in numerous blood and solid malignancies compared with a minimal expression in healthy adult tissues. Current understanding attributes a survival role for ROR1 in cancer cells; however, its oncogenic function is cancer-type-specific and involves various signaling pathways.
|Clone: 2A2||Isotype: IgG1 Mouse|
|Epitope mapping studies showed that the 2A2 clone recognized N-terminal epitopes in the extracellular region of ROR1.|