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Lactoferrin is a 76 kDa single chain polypeptide with iron-binding property. This protein shows structural similarity to the plasma iron-transport protein transferrin. Lactoferrin is involved in various immuno-regulatory functions associated with anti-infective and inflammatory responses such as antibody synthesis, cytokine production, NK cell cytotoxicity, complement activation and lymphocyte proliferation. Lactoferrin synthesis occurs at the myelocytic stage during polymorphonuclear neutrophil (PMN) ontogeny and constitutes a component of secondary (or specific) granules. Unlike the myeloperoxydase, lactoferrin is absent from primary (or azurophilic) granules and appears later during maturation of the granulocytic lineage. Thus, in peripheral blood, intracellular lactoferrin expression is restricted to neutrophils.
Isotype: IgG1 Mouse
The PE-conjugated CLB-13.17 antibody is optimized for flow cytometric detection of intracellular lactoferrin by flow cytometry after permeabilization with IntraPrep permeabilization reagent.
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.
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