CD73-PE, AD-2, 1 mL, ASR
List Price - $420.00
CD73 is a 5'-nucleotidase anchored to the membrane by a glycosylphosphatidylinositol (GPI) structure. CD73 is a dimer of two identical 70 kD subunits. A soluble form of CD73 can be shed from the membrane through proteolytic cleavage or hydrolysis of the GPI anchor by phosphatidylinositol-specific phospholipase. CD73 is expressed on subsets of T and B cells, follicular dendritic cells and on epithelial and endothelial cells. CD73 possesses the enzymatic activity of a 5'-nucleotidase and catalyzes the dephosphorylation of purine and pyrimidine ribo- and deoxyribonucleoside mono-phosphates to theirs corresponding nucleosides. An alternate function for CD73 is to regulate the availability of adenosine by converting AMP to adenosine. There is evidence that the expression and function of this enzyme are upregulated under hypoxic conditions, as well as by the presence of several pro-inflammatory mediators, such as transforming growth factor (TGF)-β interferons (IFNs), tumor necrosis factor (TNF)-α , interleukin (IL)-1 β and prostaglandin E2. CD73 can transmit activation signals to T cells and mediates adhesion of lymphocytes to follicular dendritic cells and endothelial cells. The CD73/adenosine pathway is a potent additional suppressive pathway of Treg cells and also confers a suppressive anti-inflammatory function on the uncommitted primed precursor Thpp cell type.
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The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.