CD64 Antibodies

CD64 is an integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity. It is also known as Fc-gamma receptor 1 (FcγRI) or FCRI. After binding IgG, CD64 interacts with an accessory chain known as the common γ chain, triggering cellular activation. Structurally, CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type used to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively found on macrophages and monocytes. CD64 is expressed on early myeloid cells and in IFNγ and G‑CSF activated polymorphonuclear neutrophils (PMNs).

Clone: 22 Isotype: IgG1 Mouse

The 22 antibody shows especially high affinity binding to human mononuclear phagocytes. The epitope recognized by this antibody is distinct from the IgG binding site.

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Content and Resources

SuperNova v428: New Bright Polymer Dye for Flow Cytometry Applications In this paper you will discover the latest generation of polymer dyes for flow cytometry applications – SuperNova fluorochromes.
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