CD61-UNLB, SZ21, 0.2 mg, RUO

Product No:IM0540

The CD61 antigen (platelet glycoprotein GPIIIa) is the 110 kDa integrin β3 subunit, con-covalently associated with the integrin αIIb chain (CD41, platelet GPIIb) to form the GPIIb-IIIa complex (αIIb-β3 integrin). Independently of CD41, CD61 is also associated with the integrin αV (CD51) to form the vitronectin receptor. CD41/CD61 is expressed only by platelets and megakaryocytes, whereas CD51/CD61 is found on osteoclasts, endothelial cells, macrophages, fibroblasts, smooth muscle, synovial lining cells and renal glomeruli.

Product Specifications

Target Species Human
Specificity CD61
Other Names b3 integrin, beta3 integrin, CD61, Glycoprotein IIIa, gpIIIa, Integrin beta3-chain
Fluorochrome UNLB
Regulatory Status RUO
Size 0.2 mg
Format Freeze-dried
Clone SZ21
Isotype IgG1 Mouse
Clone Description The SZ21 antibody is specific for the PlA1, not the PlA2 form of GPIIIa. It inhibits platelet aggregation and secretion induced by collagen, arachidonic acid, and thrombin. This antibody also inhibits fibrinogen binding to human platelets induced by ADP, arachidonic acid and PAF.

Customers Also Viewed