CD41-ECD, P2, 100 Tests, RUO

Product No:6607117

The CD41 antigen (platelet GPIIb; IIb integrin) is a transmembrane glycoprotein composed of two chains GPIIbα (120 kDa) and GPIIbβ (23 kDa) linked by one disulfide bond. CD41 is always non-covalently associated with CD61 (platelet GPIIIa, β3 integrin), to form the GPIIb-IIIa (CD41/CD61) complex. CD41 is expressed by platelets, megakaryocytes and a small subset of CD34+ cells, suggesting that CD41/CD61 is one of the earliest markers of the megakaryocytic lineage. The resting form of the CD41/CD61 complex binds to immobilized fibrinogen and upon platelet activation, the complex becomes a receptor for soluble fibrinogen, fibronectin, vWF, vitronectin and thrombospondin. It is involved in platelet aggregation.

Product Specifications

Target Species Human
Specificity CD41
Other Names CD41, gpIIb, integrin alpha;IIb-chain
Fluorochrome ECD
Regulatory Status RUO
Size 100 Tests
Format Liquid
Flow Product Line IOTest
Clone P2
Isotype IgG1 Mouse
Clone Description The P2 antibody reacts with the α chain of CD41a (GPIIbα) in the intact complex with GPIIIa but not with the GPIIb or GPIIIa separately. This antibody blocks binding to fibrinogen and inhibits platelet aggregation induced by thrombin, collagen and ADP. The P2 antibody was used as a CD41 reference mAb during HLDA 6.

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