CD34-SNv428, 581, 50 Tests, RUO

Product No:C76804

The CD34 antigen is a monomeric transmembrane phosphoglycoprotein of about 110 kDa with two distinct extracellular domains. The membrane proximal domain, of about 110 amino acids, probably adopts a globular conformation. The NH2-terminal domain, of about 140 amino acids, is heavily glycosylated with both N-linked glycans and sialylated O-linked carbohydrates and probably exhibits an extended rod-like structure typical of mucin-like glycoproteins. The CD34 antigen is expressed on hematopoietic progenitor cells of all lineages as well as the most primitive pluripotential stem cells. CD34 antigen expression is highest on the most primitive stem cells and is gradually lost as lineage committed progenitors differentiate. The CD34 antigen is also present on capillary endothelial cells and on bone marrow stromal cells. Variations of glycosylation are thought to occur during normal hematopoiesis depending on lineage commitment and the level of cellular maturation.

$565.00 List Price - $565.00

Product Specifications

Target Species Human
Specificity CD34
Fluorochrome SNv428
Regulatory Status RUO
Size 50 Tests
Format Liquid
Flow Product Line IOTest
Clone 581
Isotype IgG1 Mouse
Volume 0.5 x mL

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