CD28-PE, CD28.2, 2 mL, ASR

Product No:IM2071U

The CD28 antigen (Tp44) is a homodimer of disulfide-linked chains, with a molecular weight of 44 kDa each. CD28 antigen is expressed by a majority of CD3+ T lymphocytes. CD4+ T lymphocytes express the CD28 antigen more frequently than do CD8+ T lymphocytes. CD28 antigen is also present on plasma cells and thymocytes. This antigen is involved in the adhesion of T lymphocytes with B lymphocytes, through the B7/BB-1 (CD80) or B70/B7-2 (CD86) glycoproteins and provides a major co-stimulatory signal for T cell activation.

Product Specifications

Target Species Human
Specificity CD28
Other Names CD28, CD80/CD86 Ligand, Tp44
Fluorochrome PE
Regulatory Status ASR
Size 2 mL
Format Liquid
Flow Product Line IOTest
Clone CD28.2
Isotype IgG1 Mouse
Clone Description The CD28.2 monoclonal antibody costimulates T cell proliferation and cytokine production in the presence of T cell activators (αCD3, PMA, SEB). It inhibits proliferation of CD4+ T lymphocytes. It cross-reacts with Rhesus monkey peripheral blood lymphocytes.

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