CD208-UNLB, 104.G4, 0.2 mg, RUO

IM3448

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The DC-LAMP antigen (70-90 kDa) is a new member of the LAMP (lysosome-associated membrane protein) family. As other LAMP members such as CD68, DC-LAMP is a type I integral membrane protein of 416 amino acid residues, highly glycosylated (7 N- and some O- glycosylation sites), with 90% of the molecule located in the lumen of lysosomes. DC-LAMP is specifically expressed by those mature dendritic cells (DC) located in T cell areas of lymphoid tissues, which are known as interdigitating dendritic cells (IDC). A direct correlation between the expression of DC-LAMP and that of other maturation markers such as CD86 has been established. DC-LAMP first appears in the MHC Class II compartment, suggesting an important contribution of DC-LAMP to the processing of exogenous antigens.

Specifications

Target Species Human
Specificity CD208
Other Names CD208, DC-LAMP, LAMP
Fluorochrome UNLB
Regulatory Status RUO
Size 0.2 mg
Format Liquid
Clone 104.G4
Isotype IgG1 Mouse
Clone Description In flow cytometry, the 104.G4 antibody shows intracytoplasmic staining of DCs derived either from CD34+ cell cultures activated with TNFα and CD40L, or from monocyte cultures activated with TNFα, LPS and CD40L.


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The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.