How do chimeric antigen receptors (CARs) work?

FAQs об исследованиях
Chimeric antigen receptors (CARs) are designed and engineered to selectively target molecules expressed on cellular surfaces. This interaction brings the CAR-expressing cell into close proximity with the target molecule-expressing cell, thus facilitating further interactions between the two cells. By introducing tumor-associated antigen (TAA)-targeting CARs to T cells, researchers hope to promote T cell recognition and interaction with tumor cells, bypass tumor immune evasion mechanisms, and facilitate T cell-mediated tumor cell killing.1

1. S. Yu, et al., “Chimeric antigen receptor T cells: a novel therapy for solid tumors,” J Hematol Oncol 10(1):78, 2017