Are CAR-T cells used for therapeutic purposes?
CAR-T cell therapy has proven to be particularly effective against B-cell malignancies, with a more mixed record for other blood cancers and a somewhat poor record against solid tumors.1,2 Solid tumors in particular present several obstacles to CAR-T cells, including hostile microenvironments and poor accessibility.1 However, CAR design provides researchers with almost a blank slate, and the future will likely bring many more CAR-T cell-based products designed to overcome these issues.2
For the most recent data as well as trial-specific information, please visit https://clinicaltrials.gov/.
1. S. Yu, et al., “Chimeric antigen receptor T cells: a novel therapy for solid tumors,” J Hematol Oncol 10(1):78, 2017
2. J. Hartmann, et al., “Clinical development of CAR T cells-challenges and opportunities in translating innovative treatment concepts,” EMBO Mol Med 9(9):1183-1197, 2017.