Exploring Exosomes and the Tumor Microenvironment
Dr. Jan Lötvall discusses the study of extracellular vesicles and their relevance for cell-to-cell communication and how they have been implicated in several ways in disease progression. Understand the wide diversity of extracellular vesicles, with diverse morphology according to electron microscopy studies and difference in RNA and protein cargo according to bioinformatics analyses.
Various models of exosome biogenesis have been proposed. The field however, lacks the robust mechanistic studies needed to obtain a molecular understanding of vesicle secretion. Learn how one lab has taken a cargo-based approach in which the team focuses on the cis-acting signals necessary and sufficient for the budding of specific proteins. Learn from Stephen J Gould why his work supports the hypothesis that the plasma membrane is a major site of exosome budding.