Beckman.com is conducting maintenance on its shopping cart Friday, July 10th at 9 pm PST thru Sunday, July 12th at 10 pm PST. During this time, orders can still be placed by calling Client Services. We look forward to providing you an improved shopping experience.
The TCR is a molecular complexe wich comprises two units: a recognition unit, composed of either alpha-beta or gamma-delta heterodimer, which are present on the cell surface in a mutually exclusive manner, and, a transducing unit, the CD3 complex, common to alpha-beta and gamma-delta heterodimers, which triggers the T cell when the recognition unit is occupied by the antigen. The recognition unit recognizes foreign antigens and the diversity necessary for this function of recognition is generated by somatic recombination the TCR genes. There are four TCR gene loci (alpha, beta, gamma and delta). Each of them is composed of several (variable) segments, coding for about 90 amino acids, very short D (diversity) segments (alpha and delta loci only), and short J (joining) segments (about 15 amino acids), and one or two C (constant) segments. Most of T cells express the alpha/beta TCR (T cell receptor) protein and a small population of T cells expresses the gamma/delta TCR, which usually has a double negative (CD4/CD8) phenotype. Gamma/delta T-cells are normally the first line of defence at epidermal and epithelial surfaces and they represent 10-12% of lymphocytes in the spleen.
Isotype: IgG1 Mouse
The IMMU510 monoclonal antibody recognizes all γ/δ T cells, regardless of their variable chains. It stains 1.6% to 8.9% of peripheral CD3+ cells from healthy donors. In Western blot, it recognizes the δ chain in reducing conditions. It immunoprecipitates the three isoforms of the γ/δ T cell receptor. This antibody is suitable for immunohistochemistry on frozen sections. It has been used to study the distribution of γ/δ T cells and their functions.
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.
There are currently no Technical Documents associated with this page or product. Please try our Technical Documents search
Related Products or Parts
Oops. The page you wanted could not be found, so we brought you to something similar. If you still can't find what you want, try searching our site instead.