The CD79b molecule (B29, Igβ) is part of the CD79a / CD79b disulphide-linked heterodimer, non-covalently bound to surface immunoglobulins to form B cell receptors (BCR). The molecular weight of CD79b is about 33 to 40 kDa in reducing conditions. The CD79b molecule expression occurs early in B cells ontogeny. It is restricted to B lymphocytes, first appearing on the surface at the pre-B cell stage and remaining through all stages of B cell differentiation prior to plasma cells. CD79b plays an important role in the regulation of antigen receptor function like the CD3 subunits do with TCR function on T lymphocytes.
|Clone: CB3-1||Isotype: IgG1 Mouse|
|The CB3-1 antibody reacts with the external part of the CD79b molecule and is to be used in flow cytometry. This antibody is not suitable for intracytoplasmic staining. For this application the use of the CD79a antibody is recommended.|