CD109 (E123) Antibodies
The CD109 antigen is a monomeric glycosyl phosphatidylinositol (GPI)-linked glycoprotein of 170 kDa. It is a novel member of the α2 macroglobulin (α2M) / C3, C4, C5 family of thioestercontaining proteins. CD109 is found on vascular endothelial cells, some epithelial cells, activated T-cells, activated platelets, leukemic megakaryoblasts and a subset of bone marrow CD34+ cells. It is not expressed on fresh peripheral blood lymphocytes (PBL). Poorly differentiated (CD34+, TdT+, CD7+) T-acute leukemias and rare cases of chronic myeloid leukemia in megakaryoblast crisis express the CD109 antigen. Furthermore, megakaryoblastoid cell lines (MO7e, MOLM-1) are CD109+. The CD109 antigen may represent a very early marker for hematopoietic cells committed to the megakaryocyte lineage. In contrast, the adult bone marrow CD34+ CD109+ subset identifies the most primitive hematopoietic stem cells capable of long-term culture and lymphoid progenitors of the B-cell lineage.
Clone: 8A3 | Isotype: IgG2a Mouse |
Choose a CD109 (E123) Model
Product Line Specifications
Format | Liquid |
Specificity | CD109 |
Form | PE |
Clone | 8A3 |
Isotype | IgG2a Mouse |
Target Species | Human |
Flow Product Line | IOTest |
Item Specifications Referenced | A08933 |
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.