CD127 (IL-7Rα) Antigen
The CD127 antigen is a 75-80 kDa type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain CD132 (IL-2Rγ), which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21, to form the high affinity IL-7 receptor. CD127 is found on normal B cell precursors but not on mature B lymphocytes. It is also expressed by thymocytes, the majority of peripheral T lymphocytes, a subset of monocytes and a subset of CD34+ cells. CD127 is a useful marker for identifying memory and effector T cells. Its expression is down-modulated on Treg cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.
|Clone: R34.34||Isotype: IgG1 Mouse|
The R34.34 antibody inhibits binding of IL-7 to CD127.
Choose a CD127 (IL-7Rα) Model
Product Line Specifications
|Cross Reactivity||Indian Rhesus, Pigtailed Macaque|
|Flow Product Line||IOTest|
|Item Specifications Referenced||B25366|
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.