Nanoparticle Research

Leverage the power of flow cytometry for the detection and characterization of cellular origin nanoparticles

Interest in nanoparticles of cellular origin is exploding due to new insights into the role these particles play in extracellular communication processes and the potential for detecting pathological states via liquid biopsy.

Several fundamental capabilities of flow cytometry make this an attractive platform for extracellular vesicle research, such as the ability to detect large numbers of events and discriminate rare events while collecting information on surface composition.

Recent developments in laser and electronics design pushed the boundaries of reliably detecting events in the nanoparticle size range. The CytoFLEX Flow Cytometer is the first benchtop instrument with acceptable noise-to-signal discrimination for the reliable detection of particles down to 80 nm. 

Nanoparticle Resources

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How are ‘particles of interest’ measured in cleanroom and controlled processing environments?
Nanoparticle Research
Why has interest in nanoparticles of cellular origin expanded so rapidly? Because of the role they play in extracellular communication processes, and their potential for detecting pathological states; learn more here
Physical and Chemical Characterization of Nanoparticle Constructs Using the Analytical Ultracentrifuge
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Webinar covers physical and chemical characterization of nanoparticle constructs using analytical ultracentrifugation. Webinar is presented by Osman M Bakr from King Abdullah University of Science and Technology. 
Quantitative Determination of Reaction Stoichiometry, Interaction Energies, and Solute Masses Using Analytical Ultracentrifugation
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Live broadcast covering applications of analytical ultracentrifugation (AUC). 
Large Scale Purification of RNA and RNA-based Nanoparticles by Preparative Ultracentrifugation
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Webinar from Daniel Jasinski covers RNA nanotechnology in cancer therapy. RNA/RNA-based nanoparticle purification by ultracentrifugation including current technologies, different methods of ultracentrifugation, why large quantities of RNA are needed, methods for large-scale RNA purification.
Pushing the Boundaries of Nanoparticle Characterization
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Simultaneous dynamic light scattering and zeta potential. Using carbon nanotubes in Cancer therapy and characterization of nanotubes. Beckman Coulter Life Sciences presents a video on pushing the boundaries of nanoparticle characterization with ultra-fast, simultaneous dynamic light scattering and zeta potential.
Analytical Ultracentrifugation in Nanoparticle Analysis
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Joshua Robinson covers the utility of fractionation in the investigation of complex mixtures and polydisperse samples as well as versatility of analytical ultracentrifugation (AUC) for colloid chemistry. He quickly reviews analytical ultracentrifugation (AUC) theory, then discusses deconstructing nano-constructs and how AUC has been used in recent literature to really probe the underlying structure of nano-constructs, nanomaterials. Other topics covered include nanoparticle sample preparation, as well as Beckman Coulter's research and future perspectives.
Tech Note: Violet Side Scatter Use in Nanoparticle Detection
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How to Use Violet Side Scatter to Detect Nanoparticles on the CytoFLEX Flow Cytometer
MoFlo Astrios EQ Series
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Resolution: Resolves minimum 0.2μm diameter particles in forward scatter from background
MoFlo Astrios EQ
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Small Particle FSC Enhancement Module | Six-way sort purity > 99 % Purity | Integrated Bio Safety Hood: Baker SterilGARD II BSL2 Cabinet
CytoFLEX Flow Cytometer Platform Join the Resolution Revolution
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The CytoFLEX Platform is a revolutionary system presenting optimal excitation and emission, minimizing light loss and maximizing sensitivity
Characterizing RNA Nanoparticles by Analytical Ultracentrifugation
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Authors: Chad T. Schwartz, Daniel Jasinski, and Peixuan Guo - Beckman Coulter, Inc., Indianapolis, IN | University of Kentucky, Department of Pharmaceutical Sciences
Accurate, Rapid Sizing of C60 Fullerene Particles
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Author: Joshua T. Robinson | Published 2016
Density Gradient Separation of Gold Nanorods
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Gold Nanorods (AuNR) hold great promise for biomedical imaging
Particle Characterization & Centrifugation - Nanotoxicity Application Note
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Nanotechnology biomedicine is an emerging field still in its nascent phase
Particle Counting and Characterization Operator Training
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Real-world training programs to maximize your investment in particle analysis equipment.

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