TCR Vα24 Antigen

TCR Vα24 is also called TCRAV24S1 (according to the nomenclature from Arden et al.) Vα24 is the only described member of the subfamily of the T cell receptor. It has been shown to be expanded in a clonal fashion in the CD3+ CD8- CD4- cell population in PBL of several donors. It is expressed by 0.4% to 1% of peripheral CD3+ cells from normal blood. An invariant Vα24/Vβ11 T cell receptor is expressed in all individuals by clonally expanded CD4– CD8– T cells, reactive to bacterial antigens. This unique lymphocyte population restricted by the CD1d molecule recognition has been identified as the natural killer T (NKT) cells. The IGRa02 sequence is also referred to as TRAV10 (based on the IMGT gene nomenclature).