CD4-APC-A750, 13B8.2, 0.5 mL, ASR

Product No:A94685

The CD4 antigen is a single-chain transmembrane glycoprotein with a 59 kDa molecular weight. CD4 binds to a non-polymorphic region of MHC Class II molecules and is a co-receptor in MHC Class II restricted antigen-induced activation. CD4 is expressed on the T "helper" lymphocytes. It is present on most thymocytes where it is frequently co-expressed with CD8. CD4 is also expressed on all monocytes, although with a lower density than on T lymphocytes. CD4+ T lymphocytes are active in inducing and helping the synthesis of immunoglobulins by B cells. CD4 is a receptor for the Human Immunodeficiency Virus type I (HIV-1) envelope protein gp120. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.

Product Specifications

Target Species Human
Specificity CD4
Other Names CD4, T4 antigen
Fluorochrome APC-Alexa Fluor* 750
Regulatory Status ASR
Size 0.5 mL
Format Liquid
Flow Product Line IOTest
Clone 13B8.2
Isotype IgG1 Mouse
Clone Description 13B8.2 monoclonal antibody antagonizes HIV effects in vitro. 13B8.2 recognizes an epitope close to the amino-acid residues 88-89 within the CD4 molecule. 13B8.2 and BL4 recognize different epitopes. 13B8.2 and BL4 are not cross-blocking.
Cross Reactivity Hamadyras Baboon, Olive Baboon

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