CD138-PC5.5, B-A38, 50 Tests, CE

Product No:B96786

The CD138 antigen (also known as syndecan-1) is a member of the syndecan family, which is comprised of 4 types of transmembrane heparan sulfate proteoglycans macromolecules (syndecan-1, -2 or fibroglycan, -3 or N-syndecan, and -4 or amphiglycan). These molecules are involved in interactions with extracellular matrix proteins, with cell-surface molecules and with soluble proteins such as cytokines. CD138 expression in human hematopoietic cells is restricted to plasma cells in normal bone marrow. Peripheral blood monocytes, T- and B-lymphocytes are not reactive. Tonsil cells and early B-cell precursors in human bone marrow also are negative. CD138 is expressed in a variety of mature tissues, including epithelial cells, endothelial cells, fibroblasts, keratinocytes and normal hepatocytes. CD138 may act as an essential regulator of ligand-specific activation of primary signalling receptors at the cell surface, by co-engagement of various accessory ligands.

Product Specifications

Target Species Human
Specificity CD138
Other Names Syndecan-1, heparan sulfate proteoglycan
Fluorochrome PC5.5
Regulatory Status CE
Size 50 Tests
Format Liquid
Flow Product Line IOTest
Clone B-A38
Isotype IgG1 Mouse

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