CD200 is a highly conserved membrane glycoprotein that belongs to the Ig superfamily (IgSF) containing a two immunoglobulin-like domain (V, C), a single transmembrane and a short cytoplasmic domain. Diverse cell types express CD200 on surface, including thymocytes, B cells, activated T and B cells, dendritic cells, neurons and endothelia. CD200 and CD200R are highly conserved type I membrane glycoproteins, which present N-terminal immunoglobulin-like domains based interaction. While the distribution of CD200 expression is very broad, CD200R is primarily expressed in myeloid and lymphoid cells. They fulfill multiple functions in regulating inflammation interaction by promoting inhibitory activities of the immune system. The interaction between CD200/CD200R results in activation of the intracellular inhibitory pathway with RasGAP recruitment and thus contributes to effector cell inhibition. It was confirmed that the CD200R activation stimulates the differentiation of T cells to the Treg subset, upregulates indoleamine 2,3-dioxygenase activity, modulates cytokine environment from a Th1 to a Th2 pattern, and facilitates an antiinflammatory IL-10 and TGF-b synthesis. CD200/CD200R are required for maintaining selftolerance. Many studies have demonstrated the importance of CD200 in controlling autoimmunity, inflammation, inhibitory activities, hypersensitivity.
NOT ALL PRODUCTS ARE AVAILABLE IN ALL COUNTRIES
PRODUCT AVAILABILITY AND REGULATORY STATUS DEPENDS ON COUNTRY REGISTRATION PER APPLICABLE REGULATIONS
The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.