Interleukin-2 (IL-2) is a 15-17 kDa cytokine produced and secreted by T cells. The induction of IL-2 secretion is the first step in T cell activation. IL-2 is the major autocrine growth factor for activated T cells and is obligatory for the generation of cytotoxic T cells. IL-2 also promotes the proliferation and the differentiation of NK precursors, B cells and monocytes. Activated CD4+ T cells of the Th1 phenotype produce predominantly IL-2 and Interferon-γ, whereas CD4+ T cells of the Th2 phenotype produce IL-4 and IL-10.

Specifications

Specificity IL-2
Form PE
Clone N7.48A
Flow Product Line IOTest
Clone Description N7.48A-PE conjugated antibody is optimized for flow cytometric detection of intracellular IL-2 in stimulated peripheral mononuclear cells (PBMC) after permeabilizing with formaldehyde/saponin-based IntraPrep Permeabilization Reagent.
Isotype IgG2a Mouse
Format Liquid
Size 2 mL
Regulatory Status ASR
Target Species Human
Cross Reactivity N7.48A cross reacts with: Indian Rhesus
Other Names IL-2, interleukin-2
UNSPSC 41116015

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The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.