The IgGFc low affinity receptor (FCγRIII) is known to be expressed as an integral membrane protein (FcγRIIIA) and as a glycosyl-phosphatidyl inositol (GPI)-anchored protein (FcγRIIIB). These two isoforms, encoded by two different, although linked genes, have extracellular amino-acidic sequences differing by six amino acids and show specific tissue distributions. FcγRIIIB protein defines the CD16b cluster.

Specifications

Specificity CD16b
Form FITC
Clone 1D3
Flow Product Line IOTest
Clone Description The monoclonal antibody 1D3 was shown to be non-reactive with NK cells or monocytes but to be specific to polymorphonuclear leucocytes (PMNs). It recognizes an epitope specific to the FcγRIIIB molecule and was characterized as the sole antibody belonging to the CD16b cluster of differentiation. This antibody reacts with PMNs, irrespective of the neutrophil antigen (NA) phenotype, although it shows lower reactivity with NA2-homozygote PMNs as compared to NA1-homozygotes or NA1/NA2 heterozygotes.
Isotype IgM Mouse
Format Liquid
Size 2 mL
Regulatory Status ASR
Target Species Human
Other Names CD16b, Fc gamma R IIIb, FcγRIIIB, Low affinity IgG receptor
UNSPSC 41116015

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